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Get the tissues ready.

The first promo for the upcoming season premiere of “Grey’s Anatomy” has arrived.

Between the sad tears viewers will shed during the impending funeral for George O’Malley (T.R. Knight’s exit from the Seattle Grace set has been confirmed) and the apparent rebirth of Izzie Stevens (Katherine Heigl), who flatlined at the end of last season’s finale, it looks like Sept. 24 is going to be one big emotional rollercoaster.

Watch the promo below.

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